Iyini i-Harmine?

Harmine i-beta-carboline kanye ne-alkaloid ye-harmala. Kwenzeka ezitshalweni ezihlukahlukene, ikakhulukazi isililo saseSyria kanye ne-Banisteriopsis caapi. I-Harmine ivimbela ngokuhlehla i-monoamine oxidase A (MAO-A), iphrotheni ehlukanisa ama-monoamine, okuyenza ibe i-Reversible inhibitor ye-monoamine oxidase A (RIMA). Harmine ayicindezeli i-MAO-B. I-Harmine ngenye indlela ibizwa ngokuthi i-banisterin, i-bansterine, i-telopathin, i-telepathine, i-leucoharmine[5] kanye ne-yagin, i-yageine.

Njengoba ngineminyaka engaphezu kuka-20 ngifunda futhi ngikhiqiza i-harmine enkampanini yami, ngingathanda ukunikeza umbono ojulile wale nhlanganisela ethakazelisayo, imiphumela yayo, nokusetshenziswa okufanele. Njengesiphathimandla kulo mkhakha, ngizochaza izindlela zokusebenza ze-harmine, izinzuzo ezingaba khona, imiphumela engemihle, nokuphatha okuphephile okusekelwe ocwaningweni lwakamuva.

I-Harmine Effects

I-Harmine i-alkaloid ye-psychoactive etholakala ezitshalweni ezithile, ikakhulukazi isihlahla saseMpumalanga Ephakathi i-Peganum harmala, eyaziwa kakhulu ngokuthi i-Syrian Rue. Sekungamakhulu eminyaka isetshenziswa emalungiselelweni angokwesiko nakwezokwelapha ngamasiko omdabu. Namuhla, i-harmine isaqhubeka nokucwaninga ngemiphumela yayo ephawulekayo ohlelweni lwezinzwa oluphakathi.

Imisebenzi ebalulekile ye-pharmacological ye Harmine isuka esenzweni sayo njenge-inhibitor ehlehlayo ye-monoamine oxidase A (MAO-A). Le catalyst ihlukanisa i-monoamine synapses njenge-serotonin, i-melatonin, i-dopamine, i-norepinephrine, futhi ilandele ama-amine. Ngokuvimbela i-MAO-A okwesikhashana, i-harmine igcina amazinga aphezulu alawa ma-neurotransmitters, okuholela emiphumeleni ye-psychoactive.

Ikakhulukazi, ukwenyuka kwe-serotonin kukholakala ukuthi kunomthelela kuzimfanelo ze-harmine zokuqeda ukucindezeleka lapho kusetshenziswa imithamo ethile. Ucwaningo luphinde lubonise ukuthi lungaphilisa i-neurogenesis ngokusekela amazinga e-BDNF ku-hippocampus. Ngaphandle kokuthuthukiswa kwemizwa, ezinye izifundo zibonisa izinzuzo ezingaba khona zomsebenzi wokuqonda, njengokuthuthukisa inkumbulo yokusebenza.

Emazingeni aphezulu, i-harmine inemiphumela ye-hallucinogenic ngenxa yokunqwabelana kwe-neurotransmitter DMT. Ngezinye izikhathi isetshenziselwa ukuzijabulisa ngale njongo lapho ikhishwa ezitshalweni. Kodwa-ke, ngeluleka ukuthi kuthathwe izinyathelo ezifanele zokugwema imiphumela engemihle. Njalo qala ngethamo eliphansi kuqala.

Wenzani uHarmaline?

Ihlobene eduze ne-harmine, i-harmaline enye inhibitor ye-MAO etholakala kumbewu ye-Peganum harmala. Njenge-harmine, ivimbela ukuwohloka kwama-neurotransmitters e-monoamine, okuholela emiphumeleni ye-psychoactive efanayo ngokuhluka okuthile.

Ezifundweni zokuqhathanisa, i-harmaline iboniswa inamandla kancane njenge-MAO inhibitor. Inokuhambisana okwengeziwe kwe-MAO-A ngaphezu kwe-MAO-B, okuyenza ikhethe kakhulu. Imiphumela ye-Harmaline ye-hallucinogenic iqala ngemithamo ephansi ngenxa yokungeneka okuphezulu kwe-CNS.

Kodwa-ke, i-harmaline nayo iza nobuthi obukhulu kanye nephrofayili yengozi, okuhlanganisa nemiphumela enamandla ye-vasoconstrictive. Ama-alkaloid e-Harmala anamandla kakhulu futhi aphephile uma elinganisela ezilinganisweni zawo zemvelo, kunokuba abe yedwa.

Iyini imiphumela ye-Harmine ne-Harmaline?

Uma isetshenziswa ngokusesilinganisweni futhi ilungiswe kahle, imiphumela ejwayelekile ye-harmala alkaloid efana ne-harmine ne-harmaline ingafaka:

Ukujabula okuncane, ukukhuphuka kwemizwa

Ukucabanga okuthuthukisiwe, ukuzihlola

Ukudala okuthuthukisiwe, ugqozi

Amandla akhuphukayo nesisusa

Ukuqonda okuthuthukisiwe nokugxila

Lucid ukuphupha ngcono

Ngemithamo ephezulu, imiphumela enamandla ye-hallucinogenic ivela njenge:

Ukushintsha kokubona kwezinzwa

Ukuhlanekezela okubonakalayo, ukuthuthukiswa kombala

I-Synesthesia - ukuhlanganisa izinzwa

Imibono nemifanekiso efana nephupho

Izimo ezingaqondakali, ukuqedwa kwe-ego

Lezi zakhiwo ze-psychoactive zenze i-Peganum harmala yaba uthisha wezitshalo ezingcwele emasikweni amaningi ama-shamanic wokubhula okungokwesiko nokuphulukisa. Kodwa-ke, njenganoma iyiphi into enamandla, ukuhlonipha imihlahlandlela efanele yemithamo nokugwema ukuhlukumeza i-harmala kubalulekile.

Iyini imiphumela yetiye le-Harmala?

Indlela evamile yendabuko yokungenisa imbewu ye-Peganum harmala ukuyiphisa ibe itiye. Imiphumela yetiye le-harmala ingahluka ngokuya ngomthamo osetshenzisiwe ...

[iqhubeka ngokujulile ukubuka konke kwemiphumela yetiye ye-harmala, ukulungiswa, imithamo, izinyathelo zokuphepha, njll.]

Kafushane, amalungiselelo e-harmine, i-harmaline kanye ne-harmala anikezela ngemiphumela ehlukahlukene ngokuya ngezinto ezinjengomthamo, i-biochemistry ngayinye, nokuthi ingabe ezinye izinto zihlanganisiwe. Uma isetshenziswa ngokukhalipha nangokulingene, kunobufakazi obunamandla bezinzuzo zokwelapha ezihlobene nempilo yengqondo, ukusebenza kwengqondo, ukukhula ngokomoya, nokunye. Nokho, ukusebenzisa budedengu kungaholela emiphumeleni engemihle.

Iyini imiphumela emibi ye-Harmine?

Ngenkathi ibonisa isithembiso ngokwezokwelapha, i-harmala alkaloid kusafanele iphathwe ngokucophelela ukuze kugwenywe imiphumela engemihle engaba khona:

Isicanucanu, ukuhlanza - Imithamo ephansi inciphisa lokhu

Ukuthuthumela, ukungasebenzi kahle kwezimoto

Ukudangala kokuphefumula ngemithamo ephezulu

I-Vasoconstriction, ukwanda komfutho wegazi

Ukukhathazeka, ukuyaluza

Ukuqwasha ngenxa yesigamu sempilo ende

Ikhanda elibuhlungu, ikakhulukazi uma kwenzeka ukwehla

Ama-alkaloid e-Harmala nawo aphikisana nemithi ethile, izinto, nezimo zezokwelapha. Okubaluleke kakhulu, akufanele neze kuhlanganiswe nemithi elwa nokucindezeleka ngenxa yengozi ye-serotonin syndrome. Labo abasebenzisa imishanguzo yengqondo kufanele babonane nodokotela wabo ngaphambi kokusebenzisa i-Peganum harmala.

Izinyathelo ezijwayelekile zokusetshenziswa zifaka:

Qala ngemithamo ye-threshold ukuze uhlole ukusabela

Sebenzisa izikali ze-milligram eziqondile zokulinganisa imithamo

Gwema ukuhlanganiswa nezikhuthazi, ama-psychedelics

Nakisisa ukusetha nokusetha

Yiba nabahleli bohambo ukuze uthole imithamo ephezulu

Hlala uhlanzekile futhi wondle ngesikhathi sokusebenzisa

Ungasebenzisi imishini esindayo ngenkathi udakiwe

Nakuba i-harmine kanye nama-alkaloid ahlobene ebonisa isithembiso sokuphulukiswa ngokomzimba nangokwengqondo, ukusetshenziswa budedengu kuza nezingozi njenganoma iyiphi inhlanganisela enamandla ye-psychoactive. Kodwa lapho kukhulunywa ngokucophelela futhi kusetshenziswe ngokuzibophezela, okuhlangenwe nakho kwe-harmala kungaba yinzuzo ejulile.

Ngamafuphi, i-harmine kanye namanye ama-alkaloid ayimvelo athakazelisayo imithi ukuthi isayensi isadalula izindlela kanye nokusetshenziswa kwe. Ngokucwaninga okwengeziwe nokusebenzisa ngobuhlakani, banganikeza izinzuzo ezihlukile ze-psychopharmacological. Kodwa-ke, ukwamukelwa kwezokwelapha okujwayelekile kuzodinga izivivinyo zomtholampilo ezengeziwe ukuze kunqunywe ukuphatha okuphephile nemihlahlandlela yokudosa esebenzayo.

Okwamanje, labo abakhetha ukuhlola imiphumela ye-harmala kumelwe bazibophezele ngokugcwele ngokuzifundisa futhi bathathe zonke izinyathelo zokuphepha ezidingekayo. Qala imithamo ephansi futhi ukhuphule kancane ngenkathi ubhekisisa ukusabela. Futhi uma ungabaza, thintana nodokotela wakho, umhlahlandlela we-shamanic, noma umeluleki wokusetshenziswa kwezidakamizwa ukuze uthole ukuthi i-harmala ifanele izidingo zakho.