Njengongcweti oyinhloko kulo mkhakha, ngizokwenza umqondo wokwenziwa kwe-matrine, izingxenye zomsebenzi, ukusetshenziswa, imithelela kanye nokuhleleka okusemthethweni ngenxa yobufakazi bakamuva obunengqondo.

Wenzani umatrine?

Umatine i-alkaloid etholakala ezitshalweni zezinhlobo zeSophora, ezifana nezinongo zaseShayina I-Sophora flavescens. Emithini yesintu yaseShayina, isisetshenziswe isikhathi eside ngempela emithelela yayo yokulungisa enwetshiwe. Ukuhlolwa kwamanje kwembule i-matrine inemisebenzi eminingi yemithi, okuhlanganisa:

Ukunciphisa ubuhlungu nokunciphisa

I-antiviral

I-antibacterial

Antifungal

Ukuqiniswa kweseli kanye ne-anticancer

I-Immunomodulatory

I-Hepatoprotective

I-Cardiotonic

Amandla ayo okulwa nesifo, ukunciphisa ukucasuka nobuhlungu, ukuvikela isibindi, ukusiza uhlaka olungenakuthinteka namandla enhliziyo kwenze i-matrine yaba isilungiselelo esidumile se-TCM. Ngokuvamile isetshenziswa ekuphekeni kwezimo ezifana ne-hepatitis, isifo, i-arrhythmia, ukungcoliswa kwesikhumba futhi lokho kuyisiqalo nje.

Iyini ukwakheka kwe-matrine?

Ukukhuluma ngokwenziwa, sebenzisa i-alkaloid ngeresiphi ye-athomu C15H24N2O. Igama layo le-IUPAC ngu-(5S)- 5-methyl-1-azabicyclo[4.2.0]octan-2-one. I-particle matrine iqukethe kokubili indandatho ye-quinolizidine nendandatho ye-pyridine ekwakhiweni kwayo kwe-bicyclic.

I-Matrine ingenye kuphela yama-alkaloid ambalwa ahlobene atholakala ezitshalweni zeSophora. Ezinye izingxube ezinamandla zihlanganisa i-oxymatrine, i-sophocarpine, i-sophoramine, i-N-methylcytisine, i-cytisine, sophocarpidine, leachianone kusuka lapho, isibhakabhaka siwumkhawulo. Impande iqukethe i-alkaloid ephakeme kakhulu.

Amasu okuhlolwa kwanamuhla afana ne-HPLC asivumela ukuthi silethe okungaxutshwe nalutho umatine isusa ukusetshenziswa kokwelapha. Lokhu kuqinisekisa ukuthasiswa okunembile, okuphephile uma kuqhathaniswa nawo wonke amalungiselelo wezinongo...

Iyini i-matrine insecticide?

Naphezu kwezakhiwo zayo zokwelapha, i-matrine nayo ihamba njengesifutho sesiphazamisi esinwebekayo. Ukunambitheka kwayo okunokhahlo kudikibalisa izimbungulu ekuzuzeni izitshalo. Umatine isebenza njengobuthi besisu obuthinta uhlaka oluhlobene nesisu sezimbungulu. Ucwaningo lubonisa ukuthi kuyaphoqa ngokumelene nezimbungulu ezivamile zokuvuna njengezintwala, ama-weevil kanye ne-beet armyworm ngaphandle kokulimaza izimbungulu ezizuzayo njengama-ladybugs.

Njengesibulala-zinambuzane sezitshalo esivumela i-eco-accommodating, isifutho sezinambuzane ze-matrine sinikeza inketho evikeleke kakhulu ngokungafani nama-synthetics aklanyelwe ukutshalwa kwemvelo. Itholwe ezisekelweni eziyisisekelo zesitshalo seSophora, amaqabunga kanye nembewu, umatine Isifutho sezinambuzane sinokulimaza okuncane ezilwaneni ezinomgogodla futhi sihlukana ngokushesha emini. Ngokusetshenziswa okusemthethweni, inokulawula okuthile kuzimbungulu kuyilapho ikhawulela umphumela wemvelo. Inhlangano yami inikeza isifutho sesiphazamisi semvelo esisekelwe ku-matrine esaziwa kakhulu ngabakhiqizi.

Ithini inombolo ye-CAS ye-matrine?

Inombolo yelabhulali ye-CAS ye-matrine ithi 519-02-8. Lesi sikhombi sezibalo senoveli sivumela ochwepheshe befiziksi nochwepheshe ukuthi babhekise ngqo ku-athomu ye-matrine kukho konke ukubhala okunengqondo kanye nokufakwa kwelungelo lobunikazi.

I-CAS imele Ukuphathwa Kwezingoma Ezihleliwe, erekhoda ama-synthetics avezwe kumalayisense, izindatshana zedayari kanye nokusatshalaliswa okuhlukile. Ukuze ugweme ukungaqondakali, yonke into inikezwa inombolo ye-CAS. Ngakho-ke ku-matrine, i-519-02-8 ngokuvamile ibhekisela ngokucacile kuleyo nhlanganisela yokwenziwa. Lokhu kuvumela ukuxhumana okunembayo ngaphandle kokungaqondi kuzo zonke izingxenye zesayensi nokwambulwa kwemithi.

Ibhekisela ngokufanelekile kunombolo ye-CAS ye umatine iqinisekisa ukucaca okunengqondo ngenkathi ihlola ucwaningo mayelana nezakhiwo zayo zokubuyisela kanye nezinhlelo zokusebenza. Njengompetha kulo mkhakha, ngokuvamile ngibhekisela kunombolo ye-CAS engu-519-02-8 ekuqanjweni kwami ​​okukhethekile namalayisense. Isusa noma yimiphi imibuzo mayelana nento ethile evezwayo.

Isetshenziselwa ini i-matrine?

Ngomlando omude wenhloso emithini evamile yaseShayina, i-matrine inezinhlelo zokusebenza eziningi eziwusizo. Nazi izinjongo ezijwayelekile kakhulu ze-matrine uma kubhekwa ubufakazi bomtholampilo:

I-Hepatitis Therapy - Ukufakwa kukamatine kungasiza ekwehliseni imiphumela engemihle yesifo sokusha kwesibindi kohlobo futhi kusize amandla esibindi ku-hepatitis yegciwane eqhubekayo. Igxila ekuboniseni ukuthi ingase ivimbele ukuphindaphinda kwe-HBV.

Ukusekelwa Kwezifo - I-Matrine ibonisa ngokumelene nokuzivocavoca komdlavuza ezifundweni zamaseli. Kungase kuvimbele ukwanda kwamaseli esifo futhi kusebenze i-apoptosis. Isetshenziswa eduze ne-chemotherapy ukuze uthole izinzuzo ezithuthukisiwe.

Ukungcola Kwesikhumba - Isikhumba umatine okhilimu bangakwazi ukwelapha izifo zesikhumba ezibangelwa amagciwane kanye nezinambuzane ngenxa yemithelela yayo yokulwa namagciwane. Ukwengeza kunciphisa ukuvuvukala kwesikhumba.

I-Arrhythmia - I-Matrine ingasiza ekulawuleni isigqi senhliziyo ngokuhamba njengesivimbeli sesiteshi se-potassium. Izuza ama-arrhythmias athile.

Ukukhululwa ekuphathekeni kabi - Izakhiwo ezivamile zika-Matrine ezidambisa izinhlungu zidambisa ukuhlushwa okuhlobene nezinqubo zokwelapha zesisu, imifantu, ukuvuvukala kwamalunga nezimo ezihlukahlukene.

Umhlahlandlela Ongathinteki - Umatine ibhalansi ukungakwazi ukuzwela futhi ibonise ngokumelene nomthelela wokuzwela. Ingasiza ekwelapheni isifuba somoya, i-rheumatoid joint pain, psoriasis nezinye izimo ezivuthayo.

I-Matrine ngaphezu kwalokho iyacwaningwa ukuze isize izimo ngokukhetha i-COPD, isifo sikashukela, i-HIV, ukugula kwe-neurodegenerative kanye nezinkinga zengqondo. Ngokuhlola okwengeziwe, siqhubeka sembula ukusetshenziswa okusha okuwusizo kwale nhlanganisela evumelana nezimo.

Iyini imiphumela ye-matrine?

Lapho isetshenziswa ngendlela efanele, imiphumela evamile yokuthatha umatine ingafaka:

Ukuncipha kokucasuka nokuhlushwa

Wehlise umkhuhlane

Umsebenzi we-antimicrobial ngokumelene nama-microorganisms, izifo kanye nezinto eziphilayo

Ukuvikeleka kwesibindi kanye nekhono elithuthukisiwe

Ukushaya kwenhliziyo okulinganiselwe

Isiqondiso esiphephile kanye nobutha ekunyakazeni okuzwelayo

Isithiyo sokuthuthukisa umdlavuza

Ukwakhiwa kokuchama okunwetshiwe njenge-diuretic

Izilinganiso eziphakeme ezisetshenziswa emtholampilo nazo zingaletha imiphumela eseceleni njengokugula, ukugijima, ukubola kanye nokuqubuka kwesikhumba ezigulini ezithile. Ngokufanayo nanoma yisiphi isinongo esibuyisela emuva, kuyisisekelo ukugcina imithetho yomthamo futhi ubheke izimpendulo ezingezinhle.

Ngamafuphi, i-matrine iyi-alkaloid ye-TCM eyinkimbinkimbi enomthelela omkhulu wezokwelapha. Inikeza ukudambisa njalo ukuhlushwa, ukungcola, ukucasuka, i-arrhythmias, ukuzwela, ukugula kwesibindi ngisho nokukhula okuyingozi. Noma kunjalo, iziguli kufanele zisebenzise i-matrine ngaphansi kokuqondiswa uchwepheshe ofundile ngenxa yokukhathazeka okuyingozi okungaba khona kanye nokuxhumana kwezidakamizwa. Lapho isetshenziswa ngokufanele eduze nemithi yanamuhla, i-matrine inikeza izinzuzo ezimangalisayo zokululama ezithathwe kubuhlakani bezitshalo zasendulo zaseShayina.