Njengomenzi omkhulu we-honokiol, bengidinga ukunikeza isaphulelo sethu esihlonishwayo kanye nokusebenzisana okudayisa ngemanuwali eqinisekile yale nhlanganisela evamile ebalulekile. Ngaphezu kweminyaka eyi-10 sidala i-honokiol, singochwepheshe emithonjeni yayo, amasu okukhipha, amasistimu okusebenza, ukuphepha, kanye nezinzuzo zezokwelapha ezisekelwe ebufakazini. Ngizokwabelana ngezinto ezicashile ezibalulekile abathengisi abazidingayo ukuze baqonde i-honokiol futhi bafundise amakhasimende akho.

I-Honokiol yokulala

Enye yezinjongo ezikhuthaza kakhulu ze i-honokiol isekela umsindo, ukuphumula okuphumuzayo. I-Honokiol ihamba njenge-narcotic emnene ngokukhawulela kuma-receptors e-GABA futhi isekele isenzo se-GABA ku-cerebrum. I-GABA iyi-synapse ephezulu kakhulu evimbela isenzo somqondo, ikuvumela ukuthi uvume ngokunqekuzisa ikhanda. Igxile ekuthuthukisweni kwe-honokiol isikhathi eside, ukuphumula okungcono ngenkathi inciphisa ukukhathazeka.

Amakesi ethu okuphumula e-honokiol ayinketho enhle kulabo abanenkinga yokuntula ubuthongo, ukungahlaliseki okuhlobene nokucindezeleka, noma ukuvuka okungapheli kuka-12 PM. Ukulethwa okusekelwayo kudlulisa umthelela wokuthulisa we-honokiol ngaleso sikhathi ukuze uphumule okuqhubekayo. Ngezinkinga zokuphumula zokuhlola, i-honokiol ilungile kunezidakamizwa ezingabangela ukozela okusele, ukuqina, nokwethembeka.

Ingabe i-honokiol iphephile ukuyithatha?

Ezingxenyeni ezingeziwe ezisemthethweni, i-honokiol inephrofayili yokuphepha ephezulu kakhulu enemiphumela yesibili enganakwa. Isetshenziswe ngokujwayelekile kuma-equations akhule ekhaya isikhathi eside impela. Ucwaningo olubanzi lwe-toxicology lwembula ukuthi i-honokiol inoshevu ophansi kakhulu kumamodeli ezidalwa, ngisho nasezindaweni eziningi. Isehlukaniso sethu se-honokiol sihlanzwa kakhulu kuzinkombandlela zezidakamizwa, siqinisekisa izinto eziqondile, zamahhala.

Imiphumela embalwa engavamile kakhulu yezehlakalo ihlanganisa i-discombobulation emnene, i-migraines noma i-GI ecasulwe izingxenye ezinkulu. I-Honokiol ngokufanayo ingase ixhumane nemiyalelo ephikisana nengcindezi noma okokunciphisa igazi, ngakho lezo ziguli kufanele zeluleke i-PCP yazo. Ikakhulukazi, umlando omude we-honokiol wokusetshenziswa okuvamile nokuhlolwa okuqhubekayo kusekela ukuphepha kwayo kuningi lapho isetshenziswa ngendlela efanele.

Isebenza kanjani i-honokiol?

Izingxenye zokuthi i-honokiol izuza kanjani ukuphila kahle iyinkimbinkimbi. Kunoma ikuphi, inani elikhulu lezinto zayo zithola ejenti yokupholisa i-honokiol, evimbela umdlavuza kanye nasezimpahleni zokungakhululeki.

Ucwaningo lubonisa ukuthi i-honokiol ivimbela ngokuphelele okuguquguqukayo okuvusa inkanuko njengengxenye ye-athomu kappa B. Lokhu kunengqondo ngemithelela yayo yokupholisa kanye ne-neuroprotective.

Njengokuqinisa amangqamuzana aqinile, i-honokiol ibulala ama-revolutionary mahhala kanye nokulimala kwe-oxidative okuyizici zengozi yezifo eziningi eziqhubekayo. Umkhawulo wayo we-ejenti yokuvimbela umdlavuza usekelwe kakhulu kune-vitamin E.

I-Honokiol ithuthukisa ukunyakaza kwe-GABA receptor engqondweni okuthuthukisa ukukhululeka futhi kusize ukungezwani. Leli thuluzi elikhethekile likhuthaza isitha se-honokiol sezinzuzo zokwethuka.

Izingxenye ezengeziwe ezingaphansi kocwaningo zincoma ukuthi i-honokiol ingase ivikele ama-synapses, isekele ukusebenza kwengqondo, yehlise ubuhlungu, futhi ilwe nokukhula okuthile okulimazayo ngesitha somdlavuza futhi ivune imithelela ye-apoptotic. Inhlanganisela evamile eguquguqukayo ngempela!

I-magnolia yenzani ngomzimba?

I-Honokiol ingenye yezingxube ezibalulekile ezitholakala egxolweni nasezigabeni zembewu yesihlahla seMagnolia officinalis. Amagxolo e-Magnolia isetshenziswa emithini evamile yaseShayina ukubhekana nezifo eziningi ezihlanganisa ukungezwani, ubumnyama, ubuhlungu bemisipha, isilungulela, nezinkinga zokuphumula.

Izinombolo ezinkulu zemithelela yokubuyisela ye-magnolia zivela ezingxenyeni zayo ze-bioactive honokiol futhi i-magnolol. Njenge-honokiol, i-magnolol iyinhlanganisela ye-lignan enokunciphisa okuqinile, ukuqinisa amaseli kanye nezakhiwo eziphumuzayo.

Ndawonye, ​​i-honokiol ne-magnolol etholakala ngokujwayelekile egxolweni le-magnolia kunikeza ukudambisa ukungakhululeki njalo, i-neuroprotection, ikhwalithi yokuphumula ethuthukisiwe, ukuncipha kobuhlungu nobuhlungu, kanye nokunyakaza okunamandla okuguquguqukayo okunamandla. I-honokiol yethu ehlukanisayo isiza ekudluliseni lezi zinzuzo ze-magnolia ngomcabango owengeziwe, isakhiwo esiwusizo.

Ingabe i-honokiol iyalalisa?

Nakuba i-honokiol inezindawo ezithambile ze-narcotic, ayizona izindawo ezidluliselwe zamandla zokupholisa njenge-Ambien noma i-Lunesta ezikukhipha ngempumelelo. Kunalokho, i-honokiol yehlisa ukungakhululeki futhi ithulisa isistimu yezinzwa ukuze ivumele ukuphumula okuvamile, okuwusizo.

Ibophezela kuma-receptors e-GABA njengama-synthetics avamile we-cerebrum afana ne-L-theanine, isebenzisa imithelela ekhululayo engabonakali ngaphandle kokupholisa okukhulu. Amaklayenti abika ikhwalithi engcono yokuphumula ngaphandle kokuzwa kwekhanda elibuhlungu ngosuku olulandelayo lwezithambisi zokupholisa isisombululo.

Ngakho-ke nakuba i-honokiol yabelana ngamathuluzi ambalwa nezidakamizwa zezidakamizwa, ivezwa kangcono njenge-nootropic ye-anxiolytic enemithelela yokuthuthukisa ukuphumula. Amakhasimende ethu ezimweni eziningi ayamangala ngokuvumayo ukuthi azizwa evuselelwe ekuphumuleni kwe-honokiol esikhundleni sokukhathala.

Ingabe i-honokiol yehlisa umfutho wegazi?

Okunye ukuhlola kubonisa ukuthi i-honokiol ingase ibe nomthelela ekwehliseni umfutho wegazi kulabo abanomfutho wegazi ophakeme. Ukubuyekezwa okukodwa kwathola i-honokiol ixegisa imithambo futhi yehlisa ukushaya kwe-systolic kumagundane.

Amasistimu ahlongozwayo akhumbula izinto ze-honokiol zezindlela zokuhlaba umkhosi ezisebenza nekhono le-endothelial kanye nokunwebeka kwemithambo. Uphenyo olwengeziwe kulindeleke ukuthi luqinisekise umthamo ofanelekile nokuphepha kwabantu abanomfutho wegazi ophakeme. Noma ngabe kunjalo, ubufakazi obuqhubekayo buyathembisa.

Sixwayisa labo abaseduze nabathatha izidakamizwa ze-pulse ukuze beluleke udokotela wabo oyinhloko ngaphambi kokuzama i-honokiol, njengoba imithelela ehlanganisiwe ingase yehlise i-BP ngokwedlulele. Noma ngabe kunjalo, ngaphansi kwesiqondiso sikadokotela, i-honokiol ingase ivumele ukuqiniswa kwemithamo yezidakamizwa.

Iyini imithombo yemvelo ye-honokiol?

I-Honokiol itholakala kakhulu esihlahleni sakudala seMagnolia officinalis, lapho yenzeka khona emagxolweni nasezigangeni zembewu eduze komzala wayo oseduze i-magnolol. Igama elivamile le-Magnolia elithi Hou po liyakwazi - u-Hou ubhekisela ekuqhakazeni kwe-magnolia, kuyilapho u-po esho amagxolo.

Izinhlobo ezixhunyiwe ze-Magnolia obovata, noma i-Japanese magnolia, ngaphezu kwalokho iqukethe i-honokiol futhi iye yasetshenziswa emithini yaseJapane etshalwa ekhaya. Ngaphezu kwalokho, amazinga aphansi e-honokiol ayenzeka kweminye imicu yamawolintshi. Nokho, amagxolo e-magnolia ihlala eduze kwemajini ebanzi i-hotspot evamile yobukhazikhazi yokukhipha i-honokiol nokudala ibhizinisi.

Iyini isithako i-honokiol?

Ukukhuluma ngokwenziwa, i-honokiol iyinhlanganisela ye-lignan biphenolic etholakala ku-lignocellulose ye-magnolia. Igama layo le-IUPAC yi-2-(4-hydroxy-3-prop-2-enyl-phenyl)- 4-prop-2-enyl-phenol.

Izinhlayiya ze-honokiol zihlanganisa ama-phenolic bunches amabili ahlotshaniswa neketango le-diallyl. Inomthwalo ongaphansi kwe-athomu ongu-266.33 g/mol kanye nophawu lokuthambisa luka-104-106°C. I-Honokiol inama-enantiomers amabili, amabili awo anezela ku-bioactivity yayo.

Amasu amanje avumela ukukhishwa nokuhlunga kwe-honokiol emcabangweni oyingqayizivele, into ezinzile yezithuthukisi ezinomsoco. Ukwehlukana kwethu kwe-honokiol kujwayelekile ukuze kube ngu-98%.

Ingabe i-honokiol iyi-antioxidant?

Ngempela, i-honokiol iyinhlanganisela enamandla ngokumangazayo yokuqinisa amaseli. Ucwaningo lukhombisa ukuthi umkhawulo we-ejenti yokuvimbela umdlavuza we-honokiol ugxile kakhulu kunovithamini E nezinye iziqinisi ezijwayelekile zamaseli.

I-Honokiol ibulala ama-revolutionary mahhala ayingozi angalimaza amaseli futhi anezele ekuthelelekeni. Isebenza ngamandla amaprotheni e-antioxidative emzimbeni ngezinzuzo eziyisisekelo.

Ucwaningo luphakamisa izici zokuqinisa amangqamuzana e-honokiol zithatha ingxenye ebalulekile ku-neuroprotective, ukuthulisa, ukulwa nomdlavuza kanye nemithelela ye-cardioprotective. Amakesi ethu e-honokiol asiza ekulweni nomfutho we-oxidative wempilo yonke yomzimba.

Isilinganiso se-Honokiol

Ngokusetshenziswa okungeziwe, izilinganiso ze-honokiol zansuku zonke zisuka ku-500-1000mg zihlukaniswe zibe imithamo emi-2-3. Kungcono kuthathwe ngokudla ukuze kukhuliswe ukufana. Kulolu hlu lokulinganisa, i-honokiol ingxenye enkulu ibekezelelwa kakhulu nemiphumela engabalulekile.

Imithamo ephezulu ye-2000mg usuku nosuku isetshenziswa ezinsizakalweni ezimbalwa zomtholampilo njengokwelashwa kwezifo ezihambisanayo. Ukuze welaphe inkinga yokulala, qala ngo-300-500mg honokiol ngaphambi kwesikhathi sokulala. Labo abasebenzisa imishanguzo ehlukene kufanele beluleke udokotela wabo.

Ngenkathi uthenga i-honokiol, khetha ngokungaguquki izinto kubakhiqizi abasemthethweni njengathi eziveza ukuhlolwa kwamahhala kwelebhu yomlingisi, ubuhle kanye nokungcola. Gwema izithasiselo ze-honokiol "zedili" okungenzeka zonakaliswe noma zonakaliswe.

Zonke izinto ziyalingana, ngithemba ukuthi lo mhlahlandlela unikeza ulwazi olubalulekile ku-honokiol oluzosiza esihambisana nokuhlelwa kwezimali ukuthola kangcono lo muthi ojwayelekile okhuthaza kakhulu. Uma kungeyona inkinga enkulu, xhumana neminye imibuzo, futhi ngilindele ukuqhubeka kwethu nenqubekela phambili yokunikeza izinto ze-honokiol ze-premium!

References:

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2. Ma ZG, Wang J, Jiang H, Liu DJ, Yu BY. Ukuhlolwa kwemiphumela ye-anti-neuroinflammatory ye-honokiol ku-lipopolysaccharide-stimulated microglia. J Pharmacol Sci. 2014;125(2):170-180.

3. I-Woodbury A, i-Yu SP, i-Wei L, i-García P. Imiphumela ye-Neuro-modulating ye-honokiol: ukubuyekezwa. I-Neurol yangaphambili. 2013;4:130.

4. Fischer ND, Soriano L, Fuentes E, et al. I-Honokiol: i-agonist engeyona i-adipogenic ye-PPARγ evela emvelweni. I-Biochim Biophys Acta. 2013;1830(10):4862-4870.

5. Wang X, Zhang J, Chen Y, et al. I-Honokiol inqamula i-BBB ne-BCSFB: ucwaningo lwe-pharmacokinetic. I-Eur J Drug Metab Pharmacokinet. 2011;36(4):257-262.